Here’s How Anandamide and CBD Interact

Anandamide may be partially responsible for the creating the feeling of happiness. Here’s how anandamide and CBD interact with each other.

Did you know the Endocannabinoid System (ECS) is found in almost all animals?

Whether you ingest CBD or apply it as a cream, the ECS executes the positive benefits of CBD.

One neurotransmitter called anandamide has a special role in ensuring that CBD makes it to your brain. Read on to learn how the interactions between anandamide and CBD can help you harness your body’s full potential.

The Endocannabinoid System 101 

There is still research to do on the ECS. However, scientists know that this cell-signaling system helps handle your body’s response to environmental factors like stress.

The ECS assists in regulating mood, growing muscle, and ensuring reproductive health. A few key components make up the ECS. It is important to know that the ECS works without cannabinoids like CBD, but their addition can unlock many health benefits. 


Two molecules are key for regulating systems in the body and maintaining stability: anandamide (AEA) and 2-arachidonoylglycerol (2-AG).

Anandamide, the first to be discovered, is often called”the bliss molecule” for its unique role in brain health.

Endocannabinoid Receptors

For the two endocannabinoids to function, they need to bind with either CB1 or CB2 receptors. CB1 is in the peripheral and central nervous systems, which regulate brain and spinal function. They can affect crucial brain functions like memory, concentration, and appetite.

CB2 is responsible for immune response and tissue health, but it also impacts inflammation. This is especially important for healing injuries. Inflammation also informs long-term health, like the risk of heart attack and stroke.

Is It Possible to Be ECS Deficient? 

A recent theory suggests that people with brain disorders could have a weaker ECS system or fewer endocannabinoids.

Neurotransmitter deficiencies that are present in Alzheimer’s, Parkinson’s, and even depression patients could be fixed by the introduction of cannabinoids. Cannabinoids have a unique ability to inhibit FAAS enzymes, which break down anandamide and thus extend the benefits of CBD.

Endocannabinoid deficiency may cause migraines, irritable bowel syndrome, and fibromyalgia. Since these illnesses often overlap with others, it can be difficult to treat an ECS deficiency and conclude a cannabinoid a cure.

Anandamide and CBD Health 

As the desire for more natural forms of medicine grows, scientists are looking to CBD to manage mental health. Anandamide and CBD might even work together to reduce the symptoms of disorders like schizophrenia.

A 2012 study proved that cannabidiols have antipsychotic properties because they increased anandamide signaling. For people suffering from the chronic effects of schizophrenia, the addition of CBD might reduce those symptoms. This is groundbreaking because CBD does not have the same negative side effects as many prescription drugs 

This research shows promise for patients suffering from a variety of mental illnesses. 

Evidence suggests that cannabidiol can improve fertility. It’s been proven that higher levels of anandamide during the early stages of pregnancy are helpful. 

Some studies suggest that CBD suppresses the FAAH enzyme, which breaks down anandamide. By reducing this enzyme, CBD can remain in the body longer, which increases its uptake to the CB1 receptor. Anandamide is a crucial piece of how and why CBD is so uniquely beneficial to the body in so many ways. 

Higher levels of anandamide have been found in test subjects who recently performed rigorous exercise. This accounts for “runners’ high” or the rush of feel-good energy post-workout.

Mental Health and CBD 

The World Health Organization cites depression as the leading cause of disability around the world. Many of those who suffer from depression turn to drugs, which can have devastating side effects and addictive properties.

CBD has the potential to reduce symptoms related to anxiety and depression by improving mood and creating balance in the body. In fact, CBD is able to mimic serotonin and bind to similar receptors, which is how it moves so easily through the ECS. 

The National Institute on Drug Abuse reports that CBD has the ability to decrease stress in rats. Factors like an increased heart rate can be reduced with the use of CBD and a decrease in anxiety. 

Level Up Your Anandamide

Nearly 62% of CBD users use it to treat pain, anxiety, or depression. Since your body already contains feel-good receptors, learn how to maximize your body’s potential with CBD.  

CBD has been reported to help with chronic joint pain and muscle soreness. Since your skin has CB1 and CB2 receptors, CBD applied on your skin goes through the ECS. Try a muscle salve after a workout to keep your ECS working hard. 

To reap the full benefits of CBD entering your ECS and triggering anandamide to improve brain function, choose an oral method. Oil tinctures or Gel Caps facilitate an easy entry point for CBD to the body. 

It is possible for the body to get used to CBD, so be sure to find the correct dosage. There are many ways to increase your “bliss molecule” that can supplement a CBD routine. Try practicing yoga, running, or even eating certain foods. 

Boost your anandamide by eating chocolate and maca root. Both inhibit the FAAS enzyme and enhance the ECS. Keep a healthy balance of fatty acids and try to avoid excess alcohol, sugars, and trans fats. These can disrupt the ECS. 

Know Your ECS 

It is clear that the ECS is crucial for maintaining stability and preserving both mental and physical health. Anandamide and CBD hold promise as a low-risk alternative to pharmaceuticals.

If you’re looking to add CBD to your routine, take a look at our numerous products that are sourced sustainably and third-party lab tested. At Herbal Fracture, our rigorous standards are sure to positively impact your health journey and ensure a productive ECS.